Made a preliminary study on a new psychotherapeutic drug AF 1161 (chlorophenil-piperazine-propil-triazol-piridinine HCl) which has a sedating effect on behavior and reduces reaction toward negative stimuli. 36 17-63 yr. old Ss suffering from neurotic, depressive, and schizophrenic syndromes were treated. The effects of the drug were evaluated especially in relation to some primary symptoms, e.g., anxiety, asthenia, insomnia, etc. The drug was ineffective in the neurotic and dissociative syndromes during the productive phase. Satisfactory results were obtained in the depressive syndromes and in 6 cases of schizophrenic defect. The best results were obtained from Ss in which a strong anxious component was not present. It is concluded that AF 1161 is a drug of difficult classification, which joins a certain antidepressive action with a socializing action. (31 ref.) ((c) 1997 APA/PsycINFO, all rights reserved)
Il problema della valutazione pre-clinica dei nuovi farmaci psicotropi.Prime osservazioni cliniche sull'attivita' di un nuovo psicofarmaco (AF 1161).
TANSELLA, Michele;
1969-01-01
Abstract
Made a preliminary study on a new psychotherapeutic drug AF 1161 (chlorophenil-piperazine-propil-triazol-piridinine HCl) which has a sedating effect on behavior and reduces reaction toward negative stimuli. 36 17-63 yr. old Ss suffering from neurotic, depressive, and schizophrenic syndromes were treated. The effects of the drug were evaluated especially in relation to some primary symptoms, e.g., anxiety, asthenia, insomnia, etc. The drug was ineffective in the neurotic and dissociative syndromes during the productive phase. Satisfactory results were obtained in the depressive syndromes and in 6 cases of schizophrenic defect. The best results were obtained from Ss in which a strong anxious component was not present. It is concluded that AF 1161 is a drug of difficult classification, which joins a certain antidepressive action with a socializing action. (31 ref.) ((c) 1997 APA/PsycINFO, all rights reserved)
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