IgG4-RD is a recently-recognized multi-organ system condition with pathological features that are consistent across a wide range of organ systems. This condition unifies a large number of medical diagnoses previously regarded as confined to single organ systems. The precise links between the full histopathological picture of IgG4-RD, the frequent serum elevations of IgG4, and the finding of increased IgG4-bearing plasma cells in tissue remain to be ascertained fully. The use of a shared nomenclature will facilitate efforts to understand better this emerging condition and its larger implications for the immune system
Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations
ZAMBONI, Giuseppe;
2012-01-01
Abstract
IgG4-RD is a recently-recognized multi-organ system condition with pathological features that are consistent across a wide range of organ systems. This condition unifies a large number of medical diagnoses previously regarded as confined to single organ systems. The precise links between the full histopathological picture of IgG4-RD, the frequent serum elevations of IgG4, and the finding of increased IgG4-bearing plasma cells in tissue remain to be ascertained fully. The use of a shared nomenclature will facilitate efforts to understand better this emerging condition and its larger implications for the immune system
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