The title polytripeptides were synthesized and studied experimentally, by circular dichroism, and theoretically, by quantum mechanical methods. With the exception of poly(Gly-Pro-Val), which was found to be essentially structureless in solution, the other polymers adopt folded conformations, most probably of type II β-bends. Conclusions from theoretical studies were generally in agreement with the experimental results. In particular, it is noteworthy that the optimized (φ, ø) maps for poly(Gly-Pro-Met) showed the absolute minimum (φ = 60°, ø = 0°) located inside the βII bend space.

Conformational studies on polypeptide models of collagen. Poly(Gly-Pro-Val), poly(Gly-Pro-Met), poly(Gly-Val-Pro) and poly(Gly-Met-Pro)

GUANTIERI, Valeria;
1987-01-01

Abstract

The title polytripeptides were synthesized and studied experimentally, by circular dichroism, and theoretically, by quantum mechanical methods. With the exception of poly(Gly-Pro-Val), which was found to be essentially structureless in solution, the other polymers adopt folded conformations, most probably of type II β-bends. Conclusions from theoretical studies were generally in agreement with the experimental results. In particular, it is noteworthy that the optimized (φ, ø) maps for poly(Gly-Pro-Met) showed the absolute minimum (φ = 60°, ø = 0°) located inside the βII bend space.
1987
β-bend; CD; collagen models; PCILO calculations; polytripeptides
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/430185
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