The intestinal pharmacokinetics of Ciprofloxacin (Cpx) is modified by Itraconazole (Itz), a strong inhibitor of the hepatic metabolism (1). In order to better understand the mechanisms involved in the interaction we studied the distribution of Cpx in the gastrointestinal compartement and the expression of the pharmaco-metabolizing system CYP450 and P-gp in the intestine and liver.
Drug-Interaction: effects of itraconazole on the intestinal pharmaco-metabolizing system and ciprofloxacin pharmacokinetics
BENINI, Anna;BERTAZZONI MINELLI, Elisa
2011-01-01
Abstract
The intestinal pharmacokinetics of Ciprofloxacin (Cpx) is modified by Itraconazole (Itz), a strong inhibitor of the hepatic metabolism (1). In order to better understand the mechanisms involved in the interaction we studied the distribution of Cpx in the gastrointestinal compartement and the expression of the pharmaco-metabolizing system CYP450 and P-gp in the intestine and liver.
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