The intestinal pharmacokinetics of Ciprofloxacin (Cpx) is modified by Itraconazole (Itz), a strong inhibitor of the hepatic metabolism. To better understand the mechanisms involved in the interaction we studied the distribution of Cpx in the gastrointestinal compartment and the expression of the pharmaco-metabolizing system CYP450 and P-gp in the intestine and liver.

Drug interaction: effects of itraconazole on the intestinal pharmaco-metabolising system and ciprofloxacin pharmacokinetics

BERTAZZONI MINELLI, Elisa;BENINI, Anna
2012-01-01

Abstract

The intestinal pharmacokinetics of Ciprofloxacin (Cpx) is modified by Itraconazole (Itz), a strong inhibitor of the hepatic metabolism. To better understand the mechanisms involved in the interaction we studied the distribution of Cpx in the gastrointestinal compartment and the expression of the pharmaco-metabolizing system CYP450 and P-gp in the intestine and liver.
2012
Drug interaction, itraconazole, intestinalpharmaco-metabolising system, ciprofloxacin
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/417339
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact