A whole genome association study reported a SNP at -35Kb from the HLA-C gene strongly associated to HIV-1 viral set point and HLAC expression level (Fellay J. et al., 2007). HLA-C is not down-modulated by HIV-1 Nef and can be specifically incorporated in viral membrane enhancing infectivity and resistance to neutralizing antibodies (Cosma A. et al., 1999). We investigated the role of HLA-C in modulating HIV-1 infectivity using cell fusion and pseudovirus infection models and the interaction between HLA-C and Env at membrane level and in purified fusion complexes.

Presence and role of HLA-C in HIV-1 infection

MATUCCI, Andrea;ROSSOLILLO, Paola;TURCI, Marco;RACCHIOLLI, Pierpaolo;ZIPETO, Donato
2009

Abstract

A whole genome association study reported a SNP at -35Kb from the HLA-C gene strongly associated to HIV-1 viral set point and HLAC expression level (Fellay J. et al., 2007). HLA-C is not down-modulated by HIV-1 Nef and can be specifically incorporated in viral membrane enhancing infectivity and resistance to neutralizing antibodies (Cosma A. et al., 1999). We investigated the role of HLA-C in modulating HIV-1 infectivity using cell fusion and pseudovirus infection models and the interaction between HLA-C and Env at membrane level and in purified fusion complexes.
HIV-1; HLA-C; AIDS
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/340250
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 0
social impact