CPX induce DNA damage in lymphocytes in combination with a reduced efficiency in detoxification system. This effect does not seems to depend on high intersubject variability for FQs administered doses, co-administration of other drugs, different ages of patients and low samples numbers. Effects of single FQs molecules seems to be structurespecific and selective.
Fluoroquinolones effects on patients lymphocytes during prolonged treatments
BERTAZZONI MINELLI, Elisa;BENINI, Anna;DORIA, Denise;FRANCESCHETTI, Paola;FRACASSO, Maria Enrica
2006-01-01
Abstract
CPX induce DNA damage in lymphocytes in combination with a reduced efficiency in detoxification system. This effect does not seems to depend on high intersubject variability for FQs administered doses, co-administration of other drugs, different ages of patients and low samples numbers. Effects of single FQs molecules seems to be structurespecific and selective.
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