Non steoidal anti-inflammatory drugs induce cardiovascular adverse events, and this appears to be a function of intensity and duration of treatment, irrespectively of their selectivity towards cyclo-oxygenase 2. Deteminants are the degree of inhibiton in prostacyclin synthesis and the residual capacity to synthesize thromboxane in platelets.
Nonsteroidal anti-inflammatory drugs and cardiovascular risk: is prostacyclin inhibition the key event?
MINUZ, Pietro
2008-01-01
Abstract
Non steoidal anti-inflammatory drugs induce cardiovascular adverse events, and this appears to be a function of intensity and duration of treatment, irrespectively of their selectivity towards cyclo-oxygenase 2. Deteminants are the degree of inhibiton in prostacyclin synthesis and the residual capacity to synthesize thromboxane in platelets.
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