The foundations of the modem knowledge of the cell and its constituents are tightly linked to methodological breakthroughs. The existence of the Golgi apparatus, which is the cell organelle that plays a key role in the processing and targeting of proteins, was reported by Camillo Golgi in 1898. Golgi detected this novel structure in nerve cells stained with the silver impregnation he had developed for the study of the nervous tissue. For 50 years, the Golgi apparatus stimulated cytological studies, but its reality was questioned. The morphology of the Golgi apparatus and its dignity of being a genuine cell organelle were finally recognized in the mid-1950s by electron microscopy. Linked to the name of the organelle he discovered one century ago, Golgi is thus a protagonist of the history of cytology and cell biology.
The pathway to the cell and its organelles: one hundred years of the Golgi apparatus
BENTIVOGLIO FALES, Marina;
1998-01-01
Abstract
The foundations of the modem knowledge of the cell and its constituents are tightly linked to methodological breakthroughs. The existence of the Golgi apparatus, which is the cell organelle that plays a key role in the processing and targeting of proteins, was reported by Camillo Golgi in 1898. Golgi detected this novel structure in nerve cells stained with the silver impregnation he had developed for the study of the nervous tissue. For 50 years, the Golgi apparatus stimulated cytological studies, but its reality was questioned. The morphology of the Golgi apparatus and its dignity of being a genuine cell organelle were finally recognized in the mid-1950s by electron microscopy. Linked to the name of the organelle he discovered one century ago, Golgi is thus a protagonist of the history of cytology and cell biology.
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