Nephropathy is a complication of type 2 diabetes, with increased albuminuria and reduced glomerular filtration rate (GFR) as biomarkers. Rates of progression to end-stage-renal disease are variable among patients. In this study we have examined the GFR decline in newly diagnosed T2DM.Methods: A cohort of 410 patients with newly diagnosed T2DM and with at least four serum creatinine during the follow-up period were recruited. A linear model was used to calculate the decline in eGFR. A multivariable logistic model was used to identify independent predictors of rapid eGFR decline.Results: Average follow-up was 12.4 years. The eGFR change was -0.80 +/- 2.23 ml/min/1.73 m(2) per year. Patients were arbitrarily stratified into rapid decliners (<=-3.0 ml/min/1.73 m(2) per year), moderate decliners (-2.9/-1 ml/min/1.73 m(2) per year) and slow/no decliners (>-1.0 ml/min/1.73 m(2) per year). Subjects in the 3 categories were 11.4%, 27.3%, and 61.3%, respectively. Albuminuria was the stronger predictor of rapid eGFR decline.Conclusions: A rapid decline in eGFR occurs in approximately 1 out of 10 newly diagnosed subjects. This rapid decline can be predicted by widely accessible clinical features, such as albuminuria. Identification of rapid decliners may help to reduce progression toward advanced stages of nephropathy. (C) 2021 Elsevier B.V. All rights reserved.

Glomerular filtration rate decline in T2DM following diagnosis. The Verona newly diagnosed diabetes study-12

Zoppini, G
;
Trombetta, M;Pastore, I;Brangani, C;Cacciatori, V;Negri, C;Perrone, F;Pichiri, I;Stoico, V;Rinaldi, E;Da Prato, G;Bittante, C;Bonadonna, RC;Bonora, E
2021-01-01

Abstract

Nephropathy is a complication of type 2 diabetes, with increased albuminuria and reduced glomerular filtration rate (GFR) as biomarkers. Rates of progression to end-stage-renal disease are variable among patients. In this study we have examined the GFR decline in newly diagnosed T2DM.Methods: A cohort of 410 patients with newly diagnosed T2DM and with at least four serum creatinine during the follow-up period were recruited. A linear model was used to calculate the decline in eGFR. A multivariable logistic model was used to identify independent predictors of rapid eGFR decline.Results: Average follow-up was 12.4 years. The eGFR change was -0.80 +/- 2.23 ml/min/1.73 m(2) per year. Patients were arbitrarily stratified into rapid decliners (<=-3.0 ml/min/1.73 m(2) per year), moderate decliners (-2.9/-1 ml/min/1.73 m(2) per year) and slow/no decliners (>-1.0 ml/min/1.73 m(2) per year). Subjects in the 3 categories were 11.4%, 27.3%, and 61.3%, respectively. Albuminuria was the stronger predictor of rapid eGFR decline.Conclusions: A rapid decline in eGFR occurs in approximately 1 out of 10 newly diagnosed subjects. This rapid decline can be predicted by widely accessible clinical features, such as albuminuria. Identification of rapid decliners may help to reduce progression toward advanced stages of nephropathy. (C) 2021 Elsevier B.V. All rights reserved.
2021
Type 2 diabetes
Newly diagnosed diabetes
Glomerular filtration rate
Nephropathy
eGFR decline
Cohort Studies
Diabetes Mellitus, Type 2
Disease Progression
Female
Glomerular Filtration Rate
Glomerulonephritis, IGA
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1063651
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 3
social impact