In the colonic environment, sustained Wnt–β-catenin activation in regulatory T cells promotes epigenetic rewiring toward proinfammatory RORγt + Treg cells, whose expansion parallels the disease progression from infammatory bowel disease (IBD) to manifest colorectal cancer (CRC).
Wnt–β-catenin as an epigenetic switcher in colonic Treg cells
Canè S;Bronte V
2021-01-01
Abstract
In the colonic environment, sustained Wnt–β-catenin activation in regulatory T cells promotes epigenetic rewiring toward proinfammatory RORγt + Treg cells, whose expansion parallels the disease progression from infammatory bowel disease (IBD) to manifest colorectal cancer (CRC).
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Canè S, Bronte V. Nature Immunology, 2021.pdf
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